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Use of anabolic steroids significantly decreases hdl-c (> 90%) and increases ldl-c (~50%). • lipid effects from anabolic steroid use are reversible. Masteron – drostanolone is a steroid that is going to affect your cholesterol health by reducing hdl (good cholesterol) and increasing ldl. Cardiovascular: masteron can have a significant effect on cholesterol. This can result in an increase in ldl cholesterol, as well as a decrease in hdl. Actually, dht based steroids such as winstrol, anavar and masteron have shown to have the biggest effect, when it comes to lowering hdl and increasing ldl. Dht based steroids such as the very popular anavar, winstrol, and masteron have shown to have the biggest effect, when it comes to lowering hdl. Perhaps the most serious possible side effect from masteron concerns cholesterol and the way this steroid can both cause a rise in the bad type. 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